Extramural Research Programs in the Neurosciences and Neurological Disorders

Published on AidPage by IDILOGIC on Jun 24, 2005

Purpose of this program:

(1) To support extramural research within the National Institute of Neurological Disorders and Stroke (NINDS) including: neurological science basic research that explores the fundamental structure and function of the brain and the nervous system; research to understand the causes and origins of pathological conditions of the nervous system with the goal of prevention of these disorders; research on the natural course of neurological disorders; research on mechanisms associated with stroke and other cerebrovascular disorders, effects of trauma to the nervous system, neuroplasticity and regeneration, and tumors of neural and sensory tissues; improved methods of disease prevention; new methods of diagnosis and treatment; clinical trials; drug development; development of neural prostheses for stroke and paraplegia; epidemiological research; and research training in the clinical neurosciences. Programmatic areas within this Institute support research on such topics as stroke; traumatic injury to the brain, spinal cord and peripheral nervous system; neurodegenerative disorders, including Parkinson's disease and Alzheimer's disease; brain tumors; development of artificial prosthetic devices to restore function to the damaged nervous system; convulsive disorders, including epilepsy; infectious disorders of the brain and nervous system, including AIDS; immune disorders of the brain and nervous system, including multiple sclerosis; disorders related to sleep; and pain. Programmatic areas also include neurodevelopment, repair and plasticity, channels synapses and circuits, neurogenetics, neurodegeneration, neural environment, and systems and cognitive neuroscience. Extramural research is also supported by the Office of Minority Health and Research. (2) To expand and improve the Small Business Innovation Research (SBIR) program; to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. (3) To utilize the Small Business Technology Transfer (STTR) program; to stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. The NINDS also participates in the Academic Research Enhancement Award (AREA) Program, which is intended to provide research support to institutions currently having little National Institutes of Health (NIH) support.

Possible uses and use restrictions...

Research grants may be used to provide salaries, equipment, supplies, travel and other expenses for research. The grantee institution is obliged to expend grant funds prudently for the purposes stated in the application and award document. National Research Service Awards (NRSAs) are made directly to individuals for research training in specified biomedical shortage areas, or to institutions, to enable them to make NRSAs to individuals selected by them. Each individual who receives a NRSA is obligated upon termination of the award to comply with service and payback provisions. Career Development Awards such as the Independent Scientist Awards provide support for newly independent scientists with health related degrees who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers. Mentored Clinical Research Scientist Development Awards provide support for clinically trained health professionals who need an additional period of sponsored research experience as a way to gain expertise in a research area new to the candidate or in an area that would demonstrably enhance the candidate's scientific career. The Mentored Research Scientist Development Award are of three types: Re-Entry into the Neurological Sciences (RENS) which are made to women and men who have been out of neuroscience research for at least 3 years to give them an opportunity to re-establish their skills as independent neuroscientists, the Career Development Award for Minority Scholars in Neuroscience which contribute to the further career development of Minority faculty members at eligible colleges and universities, and Mentored Research Scientist Development Awards in Translational Research to support new investigators to build a program of translational research in neurological disorders. The Mentored Patient-Oriented Research Career Development Award provide support for a period of supervised study and research for clinically trained professionals who have the potential to develop into productive clinical investigators. The Mid-career Investigator Award in Patient-Oriented Research provide support for clinicians to allow them protected time to devote to patient-oriented research and to act as mentors for beginning clinical investigators. The Collaborative Neurological Sciences Award is to develop and promote competitive neurological science research programs at predominantly minority institutions through collaborations with grantees from research intensive institutions who have NIH grant support to conduct neurological science research. SBIR Phase I grants (of approximately 6-months' duration) are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. Phase II grants are for the continuation of the research efforts initiated in Phase I that are likely to result in commercial products or processes. Only Phase I awardees are eligible to receive Phase II support. STTR Phase I grants (normally of 1-year duration) are to determine the scientific, technical, and commercial merit and feasibility of proposed cooperative effort that has potential for commercial application. Phase II funding is based on results of research initiated in Phase I and scientific and technical merit and commercial potential of Phase II application. Grant funds may be expended only for the purpose stated in the application and award document. The NINDS participates in the NIH SBIR/STTR "fast track" initiative.

Who is eligible to apply...

Research Grants: Any public, private, nonprofit, or for-profit institution is eligible to apply. For-profit institutions are not eligible for Institutional National Research Service Awards but are eligible for Individual NRSAs. All proposals are reviewed for scientific merit, for evaluation of the qualifications of the investigators, for adequacy of the research environment, and for significance of the problem. Approved proposals compete for available funds. All Career Development Program awardees must be citizens or have been admitted to the United States for permanent residence. Candidates must be nominated for the program by a nonfederal public or private nonprofit institution located in the United States, its possessions or territories. Awardees for RENS must have been accepted by a sponsoring institution, had previous training and experience in neurological science, an interruption in their careers for a period of at least three years and not more than 8 years, and be citizens or non-citizen nationals of the United States. Awardees for the Ernest Everett Just Award must be nominated for the program by an historically Black college or university, must have doctoral degree in basic or clinical science and at least one year of postdoctoral experience in a faculty or research position, and must be citizens or non-citizen nationals of the United States. Awardees for the Collaborative Neurological Sciences Award must be from a predominantly minority institution and must have a doctoral degree in a basic or clinical science area. To be eligible, postdoctoral NRSA trainees or fellows must have a professional or scientific degree (M.D., Ph.D., D.D.S., D.O., D.V.M., Sc.D., D. Eng., or equivalent domestic or foreign degree). SBIR grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed, and have no more than 500 employees). Primary employment (more than one-half time) of the principal investigator must be with the small business at the time of award and during the conduct of the proposed project. In both Phase I and Phase II, the entire research must be performed in the United States. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council. STTR grants can be awarded only to domestic small business concerns (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed and have no more than 500 employees) which "partner" with a research institution in cooperative research and development. At least 40 percent of the project is to be performed by the small business concern and at least 30 percent by the research institution. In both Phase I and Phase II, the research must be performed in the U.S. and its possessions. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.

Eligible Applicant Categories:
Eligible Functional Categories:
Credentials/Documentation

Research grants are awarded to an institution in the name of an individual investigator. Persons qualified to carry out research related to the extramural programs described above may apply for funds to support their investigations. Mentored Career Program training must be conducted under the direction of a competent sponsor. National Research Service Awards: Individual NRSA Fellowships for postdoctoral training: the candidate's academic record, research experience, citizenship, institutional sponsorship, and the proposed area and plan of training must be included in the application. Institutional Training Grants for predoctoral and postdoctoral training: The applicant institution must show the objectives, methodology and resources for the research training program; the qualifications and experience of directing staff; the criteria to be used in selecting individuals for stipend support; and a detailed budget and justification for the amount of grant funds requested. Costs will be determined in accordance with OMB Circular No. A-87 for State and local governments. For-profit organizations' costs are determined in accordance with Subpart 31.2 of the Federal Acquisition Regulations. For other grantees, costs will be determined in accordance with HHS Regulations 45 CFR, Part 74 and 92, Subpart Q. For SBIR and STTR grants, the applicant organization (small business concern) must present in a research plan an idea that has potential for commercialization and furnish evidence that scientific competence, experimental methods, facilities, equipment, and funds requested are appropriate to carry out the plan. Grant forms PHS 6246-1 and PHS 6246-2 are used to apply for SBIR Phase I and Phase II, respectively. Grant forms PHS 6246-3 and PHS 6246-4 are used to apply for STTR Phase I and Phase II, respectively.

Note:This is a brief description of the credentials or documentation required prior to, or along with, an application for assistance.

About this section:

This section indicates who can apply to the Federal government for assistance and the criteria the potential applicant must satisfy. For example, individuals may be eligible for research grants, and the criteria to be satisfied may be that they have a professional or scientific degree, 3 years of research experience, and be a citizen of the United States. Universities, medical schools, hospitals, or State and local governments may also be eligible. Where State governments are eligible, the type of State agency will be indicated (State welfare agency or State agency on aging) and the criteria that they must satisfy.

Certain federal programs (e.g., the Pell Grant program which provides grants to students) involve intermediate levels of application processing, i.e., applications are transmitted through colleges or universities that are neither the direct applicant nor the ultimate beneficiary. For these programs, the criteria that the intermediaries must satisfy are also indicated, along with intermediaries who are not eligible.

How to apply...

Application Procedure:

For regular research grants and Institutional NRSAs, request grant application form PHS 398 (Rev. May 01) from the Division of Extramural Outreach and Information Resources, National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892-7910. Telephone: (301) 435-0714, E-mail: grantsInfo@nih.gov, Website: http://grants.nih.gov/grants/forms.htm. Complete application forms and return to the Center for Scientific Review, National Institutes of Health, Rockledge II, Room 1040, 6701 Rockledge Drive, Bethesda, MD 20892-7710. Telephone: (301) 435-0715. Research Fellowships: Prior to formal application, a candidate must be accepted at an institution and have a sponsor who will supervise the training. Fellows may be sponsored by a (domestic or foreign) private or public institution. Application form 416-1 (Rev. 12/98) should be used for this program. Application forms and information concerning current areas of science being supported under the Research Fellowship Award Program should be obtained from the Division of Extramural Outreach and Information Resources National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892-7910. Telephone: (301) 435-0714, e-mail: grantsInfo@nih.gov Website: http://grants.nih.gov/grants/funding/416/phs416.htm. Application forms for Individual or Institutional NRSAs and information concerning the areas of science being supported may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, Rockledge II, 6701 Rockledge Drive, Bethesda, MD 20892-7910. Telephone: (301) 435-0714, E-mail: grantsInfo@nih.gov, Website: http://grants.nih.gov/grants/forms.htm and should be submitted to the Center for Scientific Review, National Institutes of Health, Rockledge II, Room 1040, 6701 Rockledge Drive, Bethesda, MD 20892-7710. Telephone: (301) 435-0715. This program is subject to the provisions of 45 CFR, Part 92 for State and local governments and OMB Circular No. A-110 for nonprofit organizations. Grant forms PHS 6246-1 and PHS 6246-2 are used to apply for SBIR Phase I and Phase II, respectively. SBIR and STTR Grant Solicitations and SBIR Contract Solicitation may be obtained electronically through the NIH's "Small Business Funding Opportunities" home page at http://grants.nih.gov/grants/funding/sbir.htm on the World Wide Web. A limited number of hard copies of these publications are produced. Subject to availability, they may be obtained by contacting the NIH support services contractor: phone: (301) 206-9385; fax: (301) 206-9722; E-mail: a2y@cu.nih.gov. The Solicitations include submission procedures, review considerations, and grant application or contract proposal forms. SBIR and STTR grant applications should be submitted to the Center for Scientific Review, 6701 Rockledge Drive, Room 1040 - MSC 7710, Bethesda, MD 20892-7710.

Note: Each program will indicate whether applications are to be submitted to the Federal headquarters, regional or local office, or to a State or local government office.

Award Procedure:

Research Grant and Training Program applications are reviewed initially by technical panels, composed of nongovernment scientific authorities, and by the National Advisory Neurological Disorders and Stroke Council composed of 18 leaders in medical science, education, and public affairs. Approved applications will compete on a merit basis for available funds. Formal award notices are transmitted to the grantee or awardee. All accepted SBIR/STTR applications are evaluated for scientific and technical merit by an appropriate scientific peer review panel and by a national advisory council or board. All applications receiving a priority score compete for available SBIR/STTR set-aside funds on the basis of scientific and technical merit and commercial potential of the proposed research, program relevance, and program balance among the areas of research.

Note: Grant payments may be made by a letter of credit, advance by Treasury check, or reimbursement by Treasury check. Awards may be made by the headquarters office directly to the applicant, an agency field office, a regional office, or by an authorized county office. The assistance may pass through the initial applicant for further distribution by intermediate level applicants to groups or individuals in the private sector.

Deadlines and process...

Deadlines

All new research grant and career program applications, plus all (new, competing continuation, supplemental or revised) program project and center grant applications: February 1, June 1, and October 1. All competing continuation, supplemental and revised research grant and career program grant applications: March 1, July 1 and November 1. Individual NRSA applications: April 5, August 5, and December 5. Institutional NRSAs: May 10. SBIR/STTR: April 1, August 1, and December 1.

Note: When available, this section indicates the deadlines for applications to the funding agency which will be stated in terms of the date(s) or between what dates the application should be received. When not available, applicants should contact the funding agency for deadline information.

Range of Approval/Disapproval Time

Research grants: Approximately 6 to 9 months. Career program: From 6 to 9 months. SBIR/STTR applications: About 7-1/2 months. Institutional Training Grants: From 6 to 12 months.

Preapplication Coordination

Research grant applications exceeding $500,000 direct costs in any yearly budget period will not be accepted unless the NINDS has agreed to accept the application prior to submission. This program is excluded from coverage under E.O. 12372.

Note: This section indicates whether any prior coordination or approval is required with governmental or nongovernmental units prior to the submission of a formal application to the federal funding agency.

Appeals

A principal investigator (P.I.) may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute, and subsequently, the P.I. and applicant institution may appeal to the NINDS appeals officer. A description of the NIH Peer Review Appeal procedures is available on the NIH home page http://grants.nih.gov/grants/guide/notice-files/not97-232.html.

Note: In some cases, there are no provisions for appeal. Where applicable, this section discusses appeal procedures or allowable rework time for resubmission of applications to be processed by the funding agency. Appeal procedures vary with individual programs and are either listed in this section or applicants are referred to appeal procedures documented in the relevant Code of Federal Regulations (CFR).

Renewals

By application and review in same manner as new applications. Research Career Awards may not be renewed.

Note: In some instances, renewal procedures may be the same as for the application procedure, e.g., for projects of a non-continuing nature renewals will be treated as new, competing applications; for projects of an ongoing nature, renewals may be given annually.

Who can benefit...

Health professionals, graduate students, health professional students, scientists, and researchers.

Beneficiaries
About this section:

This section lists the ultimate beneficiaries of a program, the criteria they must satisfy and who specifically is not eligible. The applicant and beneficiary will generally be the same for programs that provide assistance directly from a Federal agency. However, financial assistance that passes through State or local governments will have different applicants and beneficiaries since the assistance is transmitted to private sector beneficiaries who are not obligated to request or apply for the assistance.

What types of assistance...

Project Grants

The funding, for fixed or known periods, of specific projects. Project grants can include fellowships, scholarships, research grants, training grants, traineeships, experimental and demonstration grants, evaluation grants, planning grants, technical assistance grants, survey grants, and construction grants.

How much financial aid...

Range and Average of Financial Assistance

Research grants: $73,700 to $10,335,800; $384,500. Mentored Research Career Development Awards: $86,000 to $176,000; $146,700. Independent Scientist Research Career Awards: $63,500 to $176,400; $128,200. National Research Service Awards: $100,900 to $449,900; $206,600. Individual: $18,600 to $75,600; $38,200. SBIR: Phase I approximately $150,000; Phase II not to exceed $750,000. STTR: Phase I approximately $100,000; Phase II not to exceed $500,000. (The SBIR and STTR dollars are guidelines, not limits.)

Note: This section lists the representative range (smallest to largest) of the amount of financial assistance available. These figures are based upon funds awarded in the past fiscal year and the current fiscal year to date. Also indicated is an approximate average amount of awards which were made in the past and current fiscal years.

Obligations

(Extramural Research) FY 03 $1,277,300,000; FY 04 est $1,316,671,000; and FY 05 est $1,356,427,000.

Note: The dollar amounts listed in this section represent obligations for the past fiscal year (PY), estimates for the current fiscal year (CY), and estimates for the budget fiscal year (BY) as reported by the Federal agencies. Obligations for non-financial assistance programs indicate the administrative expenses involved in the operation of a program.

Account Identification

75-0886-0-1-552.

Note: Note: This 11-digit budget account identification code represents the account which funds a particular program. This code should be consistent with the code given for the program area as specified in Appendix III of the Budget of the United States Government.

Examples of funded projects...

Grants support research on neurological disorders such as: (1) Cerebral palsy; (2) disorders of aging including Parkinson's, Huntington's, and Alzheimer's diseases and the dementias; (3) muscular, neuromuscular and demyelinating disorders; (4) neuroendocrine studies; neural aspect of learning and behavior; (5) nervous system tumors, and infectious diseases of the central nervous system. Recently funded applications include studies designed to result in advances for a group of useful glycosidases, as well as mechanistic information for the activator protein that is required for lysosomal degradation of GM2, a glycosphingolipid involved in Tay-Sachs disease. Another study focuses on mechanisms of synapse assembly, specifically the role of membrane associated quanylate kinases in the clustering and targeting of ion channels and receptors at the synapse. One example of the long range goal of a successful competing renewal application is to provide a better understanding of the mechanisms of movement of intracellular organelles along microtubules. Such movement plays a role in the process of fast axonal transport in nerve cells. The specific aims of another funded application are to assess environmental and genetic factors as determinants of hand preference, to determine whether measures of developmental stability can explain individual differences in phenotypic expressions of hand preference and to determine whether handiness is predictive of compromised immunological functioning and/or reproductive biology. A new project is aimed at addressing a series of fundamental issues regarding the mechanisms underlying the spread of synaptic modifications in neural networks. Another series of studies will take advantage of newly developed behavioral procedures and selective ibotenic acid lesions to compare the effects of lesioning hippocampus, subiculum, entorhinal cortex, and perirhinal cortex on learning and memory. Included in this effort are multi-disciplinary clinical research centers on Parkinson's disease, stroke, head and spinal cord injury, epilepsy, and demyelinating disorders, as well as program projects and a large number of individual grants. In head and spinal cord injury research studies, particular emphasis is given to the biomedical events and metabolism following injuries, with a view toward both salvaging damaged tissue and also creating conditions in which regeneration of injured nerve cells can take place. The clinical research program sponsors clinical trials to evaluate various therapeutic approaches to head and spinal cord injury, epilepsy, multiple sclerosis and other neurologic and neuromuscular disorders. The effects of systemic cancer on the central nervous system are studied, as part of the brain and spinal cord tumor research effort.

About this section

This section indicates the different types of projects which have been funded in the past. Only projects funded under Project Grants or Direct Payments for Specified Use should be listed here. The examples give potential applicants an idea of the types of projects that may be accepted for funding. The agency should list at least five examples of the most recently funded projects.

Program accomplishments...

In fiscal year 2003, there were 2,411 competing research applications and of that number, 734 awards were made; of 398 competing NRSA applications, 120 awards were made. It is estimated that 633 competing research grants and 140, NRSAs will be made in fiscal year 2004. For fiscal year 2005, it is estimated that 858 competing research grants and 140 NRSAs will be made.

Criteria for selecting proposals...

The major elements in evaluating proposals include assessments of: (1) the scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) the soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) the degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific and technical merit of the proposed approach for achieving the Phase II objectives; (3) the qualifications of the proposed principal investigator, supporting staff, and consultants; (4) the technological innovation, originality, or societal importance of the proposed research; (5) the potential of the proposed research for commercial application; (6) the reasonableness of the budget requested for the work proposed; (7) the adequacy and suitability of the facilities and research environment; and 8) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment.

Assistance considerations...

Length and Time Phasing of Assistance

Research grant awards are made for a 12-month period with recommendation of up to 4 years of additional support. Career Program awards provide support for 3 to 5 years. Training Program awards are usually for a 12-month period with recommendation of additional support of up to a total of 5 years for predoctoral training and no more than 3 years for postdoctoral training. SBIR: Normally, Phase I awards are for 6 months; normally, Phase II awards are for 2 years. STTR: Normally, Phase I awards are for 1 year; normally, Phase II awards are for 2 years.

Formula and Matching Requirements

This program has no statutory formula or matching requirements.

Note:
A formula may be based on population, per capita income, and other statistical factors. Applicants are informed whether there are any matching requirements to be met when participating in the cost of a project. In general, the matching share represents that portion of the project costs not borne by the Federal government. Attachment F of OMB Circular No. A-102 (Office of Management and Budget) sets forth the criteria and procedures for the evaluation of matching share requirements which may be cash or in-kind contributions made by State and local governments or other agencies, institutions, private organizations, or individuals to satisfy matching requirements of Federal grants or loans.

Cash contributions represent the grantees' cash outlay, including the outlay of money contributed to the grantee by other public agencies, institutions, private organizations, or individuals. When authorized by Federal regulation, Federal funds received from other grants may be considered as the grantees' cash contribution.

In-kind contributions represent the value of noncash contributions provided by the grantee, other public agencies and institutions, private organizations or individuals. In-kind contributions may consist of charges for real property and equipment, and value of goods and services directly benefiting and specifically identifiable to the grant program. When authorized by Federal legislation, property purchased with Federal funds may be considered as grantees' in-kind contribution.

Maintenance of effort (MOE) is a requirement contained in certain legislation, regulations, or administrative policies stating that a grantee must maintain a specified level of financial effort in a specific area in order to receive Federal grant funds, and that the Federal grant funds may be used only to supplement, not supplant, the level of grantee funds.

Post assistance requirements...

Reports

Research Grants: Annual and final progress reports, including a description of results, positive and negative, and a list of any publications. Career Program: Awardee submits annual progress report. Termination notice, PHS 416-7, must be submitted upon completion of NRSA training. Reports are required after termination of National Research Service Awards to ascertain compliance with the service and payback provisions. A Financial Status Report must be submitted within 90 days after the close of each budget period for which an award has been issued.

Note: This section indicates whether program reports, expenditure reports, cash reports or performance monitoring are required by the Federal funding agency, and specifies at what time intervals (monthly, annually, etc.) this must be accomplished.

Audits

In accordance with the provisions of OMB Circular No. A-133, (Revised, June 24, 1997), "Audits of States and Local Governments," and Nonprofit Organizations," nonfederal entities that expend financial assistance of $300,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Nonfederal entities that expend less than $300,000 or more in Federal awards are exempt from Federal audit requirements for that year, except as noted in Circular No. A-133. In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal officials.

Note: This section discusses audits required by the Federal agency. The procedures and requirements for State and local governments and nonprofit entities are set forth in OMB Circular No. A-133. These requirements pertain to awards made within the respective State's fiscal year - not the Federal fiscal year, as some State and local governments may use the calendar year or other variation of time span designated as the fiscal year period, rather than that commonly known as the Federal fiscal year (from October 1st through September 30th).

Records

Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last Financial Status Report for the report period.

Note: This section indicates the record retention requirements and the type of records the Federal agency may require. Not included are the normally imposed requirements of the General Accounting Office. For programs falling under the purview of OMB Circular No. A-102, record retention is set forth in Attachment C. For other programs, record retention is governed by the funding agency's requirements.

Regulations...

Authorization

Public Health Service Act, Sections 301, 405,408, 457, 458, 459, and 487, Public Law 78-410, as amended, 42 U.S.C. 241; 42 U.S.C. 284; 42 U.S.C. 284c; 42 U.S.C. 285j; 42 U.S.C. 285j-7; 42 U.S.C. 285L-2; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564.

Note: This section lists the legal authority upon which a program is based (acts, amendments to acts, Public Law numbers, titles, sections, Statute Codes, citations to the U.S. Code, Executive Orders, Presidential Reorganization Plans, and Memoranda from an agency head).

Regulations, Guidelines, And Literature

42 CFR 52; 42 CFR 66; 45 CFR 74; Grants will be available under the authority of and administered in accordance with the PHS Grants Policy Statement and Federal regulations at 42 CFR 52 and 42 USC 241; Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications. Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR) Grant Applications.

Contact information...

Web Sites
Regional Or Local Office

Not applicable.

Note: This section lists the agency contact person, address and telephone number of the Federal Regional or Local Office(s) to be contacted for detailed information regarding a program such as: (1) current availability of funds and the likelihood of receiving assistance within a given period; (2) pre-application and application forms required; (3) whether a pre-application conference is recommended; (4) assistance available in preparation of applications; (5) whether funding decisions are made at the headquarters, regional or local level; (6) application renewal procedures (including continuations and supplementals) or appeal procedures for rejected applications; and (7) recently published program guidelines and material. However, for most federal programs, this section will instruct the reader to consult the so-called Appendix IV of the Catalog due to the large volume of Regional and Local Office Contacts for most agencies. This information is provided in Additional Contact Information (see below).

Headquarters Office

National Institute of Neurological Disorders and Stroke (NINDS), Division of Extramural Research (DER), National Institutes of Health, Department of Health and Human Services, Neuroscience Center, 6001 Executive Boulevard, Bethesda, MD 20892. Acting Director DER: Dr. Alan Willard, Suite 3309, telephone: (301) 496- 9248. The address above (include suite # below) should be used for each Program Contact: Dr. Mary Ellen Michel, Repair and Plasticity, Suite 2222, telephone: (301) 496-1447; Dr. Michael Nunn, Neural Environment, Suite 2118, telephone: (301) 496-1431; Dr. Diane Murphy, Neurodegeneration, Suite 2223, telephone: (301) 496-5680; Dr. Emmeline Edwards, Systems & Cognitive Neuroscience, Suite 2109, telephone: (301) 496-9964; Dr. Randy Stewart, Channels, Synapses & Circuits, Suite 2135, telephone: (301) 496-1917; Dr. Robert Finkelstein, Neurogenetics, Suite 2143, telephone: (301) 496-5745; Dr. John Marler, Clinical Trials, Suite 2216, telephone: (301) 496-9135; Dr. Robert Baughman, Technology Development, Suite 2137, telephone: (301) 496-1779; Grants Management Branch: Mr. Mike Loewe, Grants Management Officer, Suite 3258, Telephone: (301) 496-9231; Contracts Management Branch: Mr. Kirk Davis, Contracts Management Officer, Suite 3280, Telephone: (301) 496-1813; Dr. Alfred Gordon, Office of Minority Health and Research, Suite 2151, telephone: (301) 496-3102; Margaret Jacobs, Acting Training, Career Development and Referral Officer, Suite 2113, Telephone: (301) 496-4188.

Note: This section lists names and addresses of the office at the headquarters level with direct operational responsibility for managing a program. A telephone number is provided in cases where a Regional or Local Office is not normally able to answer detailed inquiries concerning a program. Also listed are the name(s) and telephone number(s) of the information contact person(s) who can provide additional program information to applicants.

Additional Contact Information (Appendix IV)

Due to the large volume of regional and local office contacts for most agencies, full contact information is also provided separately here in a PDF format: