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Extramural Research Programs in the Neurosciences and Neurological Disorders

Published on AidPage by IDILOGIC on Jun 24, 2005

Examples of funded projects...

Grants support research on neurological disorders such as: (1) Cerebral palsy; (2) disorders of aging including Parkinson's, Huntington's, and Alzheimer's diseases and the dementias; (3) muscular, neuromuscular and demyelinating disorders; (4) neuroendocrine studies; neural aspect of learning and behavior; (5) nervous system tumors, and infectious diseases of the central nervous system. Recently funded applications include studies designed to result in advances for a group of useful glycosidases, as well as mechanistic information for the activator protein that is required for lysosomal degradation of GM2, a glycosphingolipid involved in Tay-Sachs disease. Another study focuses on mechanisms of synapse assembly, specifically the role of membrane associated quanylate kinases in the clustering and targeting of ion channels and receptors at the synapse. One example of the long range goal of a successful competing renewal application is to provide a better understanding of the mechanisms of movement of intracellular organelles along microtubules. Such movement plays a role in the process of fast axonal transport in nerve cells. The specific aims of another funded application are to assess environmental and genetic factors as determinants of hand preference, to determine whether measures of developmental stability can explain individual differences in phenotypic expressions of hand preference and to determine whether handiness is predictive of compromised immunological functioning and/or reproductive biology. A new project is aimed at addressing a series of fundamental issues regarding the mechanisms underlying the spread of synaptic modifications in neural networks. Another series of studies will take advantage of newly developed behavioral procedures and selective ibotenic acid lesions to compare the effects of lesioning hippocampus, subiculum, entorhinal cortex, and perirhinal cortex on learning and memory. Included in this effort are multi-disciplinary clinical research centers on Parkinson's disease, stroke, head and spinal cord injury, epilepsy, and demyelinating disorders, as well as program projects and a large number of individual grants. In head and spinal cord injury research studies, particular emphasis is given to the biomedical events and metabolism following injuries, with a view toward both salvaging damaged tissue and also creating conditions in which regeneration of injured nerve cells can take place. The clinical research program sponsors clinical trials to evaluate various therapeutic approaches to head and spinal cord injury, epilepsy, multiple sclerosis and other neurologic and neuromuscular disorders. The effects of systemic cancer on the central nervous system are studied, as part of the brain and spinal cord tumor research effort.

About this section

This section indicates the different types of projects which have been funded in the past. Only projects funded under Project Grants or Direct Payments for Specified Use should be listed here. The examples give potential applicants an idea of the types of projects that may be accepted for funding. The agency should list at least five examples of the most recently funded projects.